Features from BIOTOC Connection

Spotlight: Dr. Jan Rosenbaum, President, Chief Executive Officer, & CSO at Kurome Therapeutics, Inc. - Dermafirm USA

Spotlight: Dr. Jan Rosenbaum, President, Chief Executive Officer, & CSO at Kurome Therapeutics, Inc.

August 04, 2020 5 min read

As the President, CEO, and Chief Scientific Officer (CSO) at biotech startup Kurome Therapeutics, Dr. Jan Rosenbaum does a little bit of everything—including taking out the trash. The company is based on a technology that provides “a targeted approach for treating hematological cancers and beyond.” This technology was developed by a professor at Cincinnati Children’s Hospital and two scientists at the National Center for Advancing Translational Sciences (NCATS) at the National Institute of Health. Dr. Rosenbaum was brought on as a consultant to evaluate the potential for commercializing the technology and was able to build the business case and value proposition by focusing on novel aspects of the mechanism of action that allowed for differentiation of this technology from others being developed. Kurome’s technology targets cancer cells that develop an “adaptive resistance mechanism” which allows them to survive conventional treatments and thereby subverts cancer’s ability to evade therapy. 
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Robert's Insights: What are Liposomes and how do they impact your skincare routine? - Dermafirm USA

Robert's Insights: What are Liposomes and how do they impact your skincare routine?

July 29, 2020 1 min read

Liposomes protect, transport, and release your drug or ingredients at the right place and time. “The history of liposomes goes back to mid-1960s and credit of their birth goes to Banghamand and his coworkers, who discovered that phospholipids in presence of suitable solvents form bilayered membranes which finally curl-on to form unilamellar of multiamellar vesicles. The history of liposomes can be divided into three periods: Genesis, Middle age, and Modern era. A few years later, the structural description of liposomes was unveiled as small devices made of one or more closed phospholipid bilayers.” Liposomes have been further developed by pharmaceutical and later cosmetic industries also started to use liposome technology since 1986. The major types of liposomes are the multilamellar vesicle, the small unilamellar liposome vesicle, and the large unilamellar vesicle and the cochleate vesicle.
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Industry Update: Cosmetics, Neuroscience, and Biotech - Dermafirm USA

Industry Update: Cosmetics, Neuroscience, and Biotech

July 28, 2020 1 min read

Accessible cosmetic products are on the rise as the beauty industry looks to become more inclusive. For individuals living with disabilities, such as Parkinson’s Disease, using traditional skin and makeup products can be extremely difficult. Everything from product packaging to the tools used for application can create extreme challenges for millions of consumers with disabilities.
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Did You Know? - Dermafirm USA

Did You Know?

July 28, 2020 1 min read

  1. Information from the brain travels at a whopping 268 miles per hour.
  2. Your DNA is fireproof
  3. Peanuts are used as a key ingredient in dynamite. They create an explosive liquid called nitroglycerine. 
  4. Forgetting information isn't always a bad thing as it is necessary for your brain to properly function. 
  5. Frogs do not drink water using their mouths, they absorb it through their skin.
  6. Elizabeth Blackwell was the first woman ever to receive a medical degree. She was also a strong advocate for reform in education, medicine, and women’s rights.
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Skincare Science — More than Skin-Deep  - Dermafirm USA

Skincare Science — More than Skin-Deep 

July 28, 2020 1 min read

Some of the most innovative new products in beauty have been spearheaded by scientists from all walks of life, according to Allure. The skincare industry has evolved to become one that prioritizes proven and effective results, and by embracing science, skincare has been able to delve beyond the surface. The brightest minds in science are working in labs around the world to create effective skincare, coming up with novel ideas for this cause. 
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Scientists of Color: Innovators from the Past and Present - Dermafirm USA

Scientists of Color: Innovators from the Past and Present

July 28, 2020 2 min read

Chemotherapy was once considered to be taboo before Dr. Jane C. Wright pushed to make it a standard of treatment for cancer patients. Wright began her career by working alongside her father, Dr. Louis T. Wright, at the Cancer Research Foundation in Harlem Hospital. Her father was one of the first Black men to graduate from Harvard Medical School, following her father's example of breaking through barriers. When he passed away in 1952, Wright took over as the director of the research center, where her experiments led Wright to successfully provide treatment for human cancer patients. She went on to form the American Society of Clinical Oncology to improve doctor care for cancer patients. She was the only Black woman out of the other seven male physicians on the board. Her successes did not end there as President Lyndon B. Johnson soon after appointed her to his commission.
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#BeautifulMinds: Modern Women Scientists Receiving Awards  - Dermafirm USA

#BeautifulMinds: Modern Women Scientists Receiving Awards 

July 28, 2020 2 min read

Throughout history, female scientists have made extraordinary contributions to science, such as Rosalind Franklin, who helped develop the structure of DNA, or Rachel Carson, who catalyzed the environmental movement with her book Silent Spring. However, very few women have won the Nobel Prize for their scientific achievements. Instead, men were honored for their discoveries, and women were left on the sidelines. Why have only 22 women been awarded a Nobel Prize in science, one of the most prestigious awards given to people who have made significant contributions to the field? The answer lies in implicit bias that women have been fighting for centuries. This stereotype that “women are bad at math” or “don't like science” creates barriers, blocking women from entering the industry. Since the stereotypes are reinforced early on, young girls who might pursue a career in the STEM field are left discouraged. Additionally, these implicit biases cause women to receive less credit for their work. For example, publications by women take almost twice as long to be reviewed, and many women are pressured to use their surname in order to prevent gender bias. These factors have led to the underrepresentation of women in STEM, but in rec
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Robert's Insights: What are the top DIY routines for brightening dark spots due to PIH? - Dermafirm USA

Robert's Insights: What are the top DIY routines for brightening dark spots due to PIH?

July 28, 2020 5 min read

What is Postinflammatory Hyperpigmentation (PIH)?

According to DermNet NZ, “Postinflammatory pigmentation is temporary pigmentation that follows an injury, i.e. thermal burn or inflammatory disorder of the skin (i.e dermatitis, infection). It is mostly observed in darker skin types (see ethnic dermatology). Postinflammatory pigmentation is also called acquired melanosis. More severe injury results in postinflammatory hypopigmentation, which is usually permanent.”

Permanently stopping hyperpigmentation is impossible but there are top routine tips for getting rid of post-acne marks or post-inflammatory hyperpigmentation (hereafter PIH). As indicated by DermNet NZ, anyone with darker skin types is more prone to deal with post-inflammatory hyperpigmentation. Your skin triggers pigment production overdrive after you have inflammation such as wounds, pimples, hormonal changes, irritation, or sunburn. This leaves dark spots on your skin that can be light brown or darker purplish-black spots. Many people who are in their 30's (even among teenagers) start suffering from PIH and it causes annoyance, stress, and even depression if an individual’s appearance is severely impacted by PIH.

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